They included STAT3, TP63, TP73, FOXO1, PML, DAXX, RUNX2, INSR, and PCNA. Top pathways with more than 5 gene members annotated from differentially methylated probes included the Sirtuin signaling pathway (3 hubs of 8 gene members: FOXO1, STAT3 and TP73), molecular mechanisms of cancer (2 hubs of 7 gene members: DAXX and FOXO1), p53 signaling (4 hubs of 7 gene members: PCNA, PML, TP63 and TP73), and 5' AMP-activated protein kinase (AMPK) signaling (2 hubs of 6 gene members: FOXO1 and INSR). Here, RUNX2 is linked to cancer.