Notably, HPK1 KD mice showed markedly increased pro-inflammatory pathways in response to priming with tumor antigens as shown by the enhanced related gene expression, e.g. S100A8, GZMB, NKp44, CXCL14, CX3CL1, CD1d2, KLRG1, CD11c, NLRP3 and MUC1. The gene discussed is CX3CL1; the disease is neoplasm.