Notably, HPK1 KD mice showed markedly increased pro-inflammatory pathways in response to priming with tumor antigens as shown by the enhanced related gene expression, e.g. S100A8, GZMB, NKp44, CXCL14, CX3CL1, CD1d2, KLRG1, CD11c, NLRP3 and MUC1. Here, S100A8 is linked to neoplasm.