NLRP3 and neoplasm: Notably, HPK1 KD mice showed markedly increased pro-inflammatory pathways in response to priming with tumor antigens as shown by the enhanced related gene expression, e.g. S100A8, GZMB, NKp44, CXCL14, CX3CL1, CD1d2, KLRG1, CD11c, NLRP3 and MUC1.