The lung has been proposed to have pro-oxidant environment due to high oxygen and toxins exposure (Schild et al., 2018), and anti-oxidative mediators such as NRF2 (Wang et al., 2016; DeNicola et al., 2015; Menegon et al., 2016), peroxiredoxin 2 (Stresing et al., 2013) and thioredoxin-like 2 (Qu et al., 2011) stimulate the progression of lung cancer and lung metastasis. The gene discussed is NFE2L2; the disease is lung cancer.