Our selection of this intervention was twofold: aerobic exercise training is a well‐documented countermeasure to obesity and T2DM that confers benefit through skeletal muscle adaptations, and aerobic exercise training has been previously shown to stimulate Nur77 and NOR1 gene expression (Chao et al. The gene discussed is NR4A1; the disease is obesity due to melanocortin 4 receptor deficiency.