While preclinical and human studies have described defects in Nur77 and NOR1 in obesity (4; 9‐11), the data herein deepen our understanding of how skeletal muscle Nur77 and NOR1 may function across a range of human phenotypes: LHC, to OB and T2DM. Here, NR4A3 is linked to obesity due to melanocortin 4 receptor deficiency.