Skeletal muscle Nur77 and NOR1 protein expression increased in response to insulin stimulation in LHC (Nur77: 8.7 ± 3.2‐fold, P < 0.01; NOR1: 3.6 ± 1.1‐fold, P < 0.05), but remained unchanged in OB (Nur77: 1.0 ± 0.3‐fold, P > 0.05; NOR1: 1.0 ± 0.1‐fold, P > 0.05) and T2DM (Nur77: 1.1 ± 0.1‐fold, P > 0.05; NOR1: 1.0 ± 0.1‐fold, P > 0.05) (Fig. 1A–D). Here, NR4A1 is linked to type 2 diabetes mellitus.