Peroxisome proliferator‐activated receptor gamma (PPARγ), a member of the nuclear receptor family of ligand‐activated transcription factors that regulates gene expression via the formation of protein heterodimers with the retinoic X receptor (RXR), is a key nuclear receptor regulating adipocyte differentiation and glucose homeostasis.10 Peroxisome proliferator‐activated receptor gamma has been reported to interact with multiple signalling pathways, including BCL2, NFκB, p53, p21, STAT, cyclooxygenase‐2 (COX‐2) and Cyclin D1.11 Additionally, PPARγ is highly expressed in certain cancer cell. The gene discussed is PPARG; the disease is cancer.