However, we found a higher level of PD-L1, PD-L2, CD80, CD86, Tim-3, LAG3, and 4-1BB in EBV-positive STAD and cytomegalovirus-positive colon and rectum adenocarcinoma than in virus-negative tumor samples (Fig. 2b–d). Here, LAG3 is linked to rectum adenocarcinoma.