Tumors with high T-cell signatures from our clustering analysis are concordant with high expression of PD-L1, PD-L2, PD-1, CD80, CD86, CTLA-4, Tim-3, LAG3, 4-1BB, CD8, and CD4, EBV-positive status (Fig. 5), and low tumor purity and high immune score (Supplementary Fig. 6b, d). This evidence concerns the gene CTLA4 and neoplasm.