Yet, deregulation of mitochondrial metabolism could be considered a potential therapeutic target in tumor resistance.114 Because the PGC-1α/ERRα network is a master regulator of mitochondrial biogenesis, it could be considered a nodal regulatory step capable of controlling the entire cellular metabolism and, at least in part, in modulating this resistance-related mechanism in cancer, leading to cancer recurrence (Fig. 1).115,116. The gene discussed is ESRRA; the disease is neoplasm.