Their attenuation of the immune response helps tumor cells survive by evading the immune system.53 Pembrolizumab, a monoclonal antibody against PD-1, confirmed that blocking PD-1 and PD-L1 in the immune system could significantly increase the overall survival rate in cancer patients.54 PD-1 is thus an attractive target for immunotherapy and PD-1 inhibitors have been recently approved by the U.S. Food and Drug Administration (FDA) for cancer immunotherapy. Here, CD274 is linked to cancer.