AKT1 and breast cancer: miR-143 is one of the representative TS-miRNAs that is poorly expressed in a variety of cancers, including BC.8, 9, 10 miR-143 has been shown to act as a tumor suppressor in non-small-cell lung cancer,11 cervical cancer,12 prostate cancer,13 ovarian cancer,14 colon cancer,15 and leukemia16, 17 and to silence not only K-RAS18 but also RAS-effector signal genes Erk and Akt.19