Therefore, miR-143#12, which extremely silenced K-RAS and its effector-signaling molecules Akt and Erk, as well as SOS1, could induce a potent anti-tumor effect with apoptosis in K-RAS-dominant 253J-BV BC cells, which reflected the induction of apoptosis in the case of K-RAS mutant T24 BC cells. Here, AKT1 is linked to breast cancer.