HIF1A and Hyperglycemia: Catrina et al. first noticed that hyperglycaemia impaired HIF-1α protection under hypoxia in human diabetic ulcers and pointed out the molecular mechanism connecting hyperglycaemia and hypoxia sensitivity [3], and Mace et al. disclosed that compared to nondiabetic, hypoxia-inducible factor- (HIF-) 1α expression was markedly decreased in skin wounds of diabetic mice [4].