DDX41 and coronary artery disorder: Similarly, T. cruzi-specific anti-α-Gal Abs purified from acute and chronic ChD patients have cytotoxic (trypanolytic) effects on both metacyclic trypomastigotes and TCT forms of the parasite in vitro.19,20,22 Next, we purified anti-α-Gal Abs produced by α1,3GalT-KO mice to investigate whether these Abs are also trypanolytic.