Furthermore, the anti-α-Gal Abs, purified from α1,3GalT-KO mice, were lytic to TCTs in a complement-independent manner, as previously demonstrated for human Ch anti-α-Gal Abs.22 We have also shown here that purified murine anti-α-Gal IgG Abs could effectively block host cell infection and intracellular proliferation of the parasite. Here, DDX41 is linked to infection.