NOS2 and bacterial infectious disease: Radiation combined with wound trauma results in a decrease in the levels of lymphocytes, macrophages, neutrophils, platelets, cell adhesion molecules, tissue integrity, and stem cells, but leads to an increase in the activity of the iNOS/NF-kB/NF-IL6 and p53/Bax pathways, TLR signaling, cytokine concentrations [134], bacterial infection, cytochrome c release from mitochondria to cytoplasm, and DNA single and double strand breaks.