On one hand, on the basis of the currently putative opinion, the oxidative inactivation of phosphatases including PTPs and PTENs by H2O2 at appropriately high levels triggers signaling transduction and crosstalk among signaling pathways to support uncontrollable growth of cells, resulting in tumorigenesis, angiogenesis, and metastasis of cancer cells [10–14]. The gene discussed is PTS; the disease is cancer.