Geraldes et al. [30] further found hyperglycemia persistently activated PKCδ and p38α MAPK to increase the expression of a novel target, Scr homology-2 domain containing phosphatase-1 (SHP-1), leading to PDGF receptor-β dephosphorylation and actions, and increased pericyte apoptosis, independent of NF-κB, and Chen et al. [31] reached the similar conclusion. Here, PRKCD is linked to Hyperglycemia.