Correspondingly, higher PTTG1 expression in MTC patients was associated with advanced stage of disease (stages III and IV) with extracapsular extension (T3 and T4), with lymph node metastases (N1) and persistence of disease, suggesting a potential prognostic value for PTTG1 in sporadic MTC. The gene discussed is PTTG1; the disease is medullary thyroid gland carcinoma.