TGFB1 and colorectal carcinoma: Moreover, we observed the transforming growth factor (TGF)-β /SMAD signaling was disrupted by DNA methylation as a shared component in angiogenesis, negative regulation of TGF-β receptor signaling pathway, regulation of TGF-β production and CRC pathway (GO: 0001525, GO: 0030512, GO: 0032909 and hsa05210, respectively).