Two of the SNPs significant for penumbra volume were also significant at the 6-hour time point, rs31452396 and rs13472659, the latter of which is in Clint1. While rs13472659 is a synonymous coding SNP, it was found to be significant in two separate analyses is suggestive of its relevance to cerebral ischemia. Here, CLINT1 is linked to brain ischemia.