TSFM and hypertrophic cardiomyopathy: Mutations in the TSFM gene [i.e. the homozygous p.(Arg312Trp) change, in a subdomain of EF-Ts interacting with EF-Tu], have been previously demonstrated in infantile cases of severe hypertrophic cardiomyopathy with or without encephalomyopathy18,23, or liver failure24, leading to death in the first months of life.