MFN2 and peripheral neuropathy: We uncovered an alteration of folic acid (FA) metabolism transcripts in flies with downregulated dMfn. We show that both dietary and genetic interventions to enhance FA metabolism partially supressed the defects observed in adult flies lacking dMfn. We conclude that strategies to enhance FA metabolism may prevent or delay the axonal defects in MFN2-linked CMT2a and other peripheral neuropathies associated with mitochondrial dysfunction.