GZMA and leukemia: Most interestingly, despite no enrichment for leukemia-specific T cells was performed in vitro, a higher proportion of IR+ lymphocytes recognized autologous leukemic blasts compared with IR− cells in vitro, as demonstrated by granzyme A and B production (IR+ and IR−: 762.6 pg/mL, vs. 0 pg/mL; p < 0.001; Fig. 5f) and cytotoxicity (elimination index: 62.2% for IR+ vs. 43.5% for IR− at 100:1 E:T ratio; p < 0.05; Fig. 5g).