As shown in this study, several genes in KEGG pancreatic cancer pathways are more similar to their human homologs in terms of protein sequence and post-translational modification sites, including Tp53 (Tong et al., 2017), P16Ink4a/P14Arf and P15Ink4b, which are most frequently mutated in human PDAC and were applied to induce pancreatic cancer in this study. Here, TP53 is linked to familial pancreatic carcinoma.