Moreover, the tumors expressed some well-established markers of human pancreatic cancer, including the ductal markers CK19 (Fig. 3E,F), mucin 5 (Muc5) (Fig. 3G,H), matrix metalloproteinase 7 (MMP7) (Fig. 3I,J), and hairy and enhancer of split 1 (Hes1), the indicator of the active Notch signaling pathway (Fig. 3K,L). This evidence concerns the gene HES1 and familial pancreatic carcinoma.