CYP3A4 and hypertensive disorder: Recently, previous study reported that the A-allele of CYP3A4 rs4646437 was associated with an increased risk for hypertension (odds ratio [OR]=2.4, 95% confidence interval [95% CI]: 1.10–5.20, P=0.021) in metastatic renal cell carcinoma patients treated with sunitinib [19].