In conclusion, our work found that DANCR had promoting functions on cell proliferation, invasion, and migration in breast cancer through working as ceRNA to target miR-216a-5p, which indicated that the new axis of DANCR/miR-216a-5p might provide a potential therapy target for breast cancer treatments, not only TNBC but also ER-positive breast cancer. The gene discussed is DANCR; the disease is breast carcinoma.