As shown in Figure 2, FAM83D mRNA was up-regulated in approximately 8% HCC patients, no up-regulation of FAM83D mRNA was found in other histological malignancies including HCC plus intrahepatic cholangiocarcinoma, fibrolamellar carcinoma and hepatobiliary cancer (Figure 2). This evidence concerns the gene SACK1D and intrahepatic cholangiocarcinoma.