Interactions between SIRPα on phagocytic cells and CD47 on phagocytosed targets, such as erythrocytes, cancer cells, and apoptotic cells, act as a ‘don’t eat me’ signal and thereby control erythrocyte homeostasis, elimination of cancer cells, and the formation of arteriosclerotic plaques (Chao et al., 2011; Ishikawa-Sekigami et al., 2006; Kojima et al., 2016; Willingham et al., 2012). Here, SIRPA is linked to cancer.