6.8 (https://david.ncifcrf.gov/) (Huang et al., 2009a; Huang et al., 2009b) suggested that the genes whose expression increased in the white matter of CD47 KO mice were significantly enriched in pathways such as infectious diseases, phagocytosis, and immune responses, probably reflecting the activation of microglia (Figure 5A). This evidence concerns the gene CD47 and infectious disease.