TNF and cancer: Genes whose expression increased in CD47 KO brain cells were significantly enriched in pathways for T cell receptor signaling, axon guidance, proteoglycans in cancer, TNF signaling, and NF-κB signaling (Figure 5A); genes whose expression decreased in CD47 KO brain cells were enriched in cancer-associated pathways including Wnt, Hippo, and Rap1 signaling, as well as cardiomyopathy (Figure 5B).