TREM2 and Alzheimer disease: It is also notable that the gene sets that were increased in the white matter of CD47 KO mice (i.e. Itgax, lpl, Cst7, Clec7a, Trem2, and Tyrobp) were similar to those increased in DAM (disease-associated microglia), a potential protective microglia subtype associated with neurodegenerative conditions such as AD (Keren-Shaul et al., 2017).