The mammalian ortholog QSOX1 has been shown to affect disulfide bond formation, is overexpressed in some cancers, promotes Matrigel invasion, and can serve as a negative prognostic indicator in human cancer patients (Chakravarthi et al., 2007; Katchman et al., 2011; Lake and Faigel, 2014). This evidence concerns the gene QSOX1 and cancer.