COL11A2 and metabolic syndrome: For instance, in a study investigating the contribution of genetic and epigenetic factors in the development of the metabolic syndrome, 2 methylation quantitative trait loci (meQTL) disrupting CpG sites located within the COL11A2 gene were revealed for associations with the metabolic syndrome and its components in obese individuals, and interestingly, CpG cg16507569 showed a reduction in methylation levels in the presence of a minor allele of rs114894582 [17].