Antigen Presentation Pathway, the primary pathway, included 5 genes: NLRC5 (NLR Family CARD Domain Containing 5), HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), HLA-B (Major Histocompatibility Complex, Class I, B), TAP1 (Transporter 1, ATP Binding Cassette Subfamily B Member) and HLA-DRB5 (Major Histocompatibility Complex, Class II, DR Beta 5) which were found to be associated with obesity in the current study. This evidence concerns the gene NLRC5 and obesity due to melanocortin 4 receptor deficiency.