RT-PCR revealed that the mRNA expressions of c-Jun and c-Fos significantly increased (p < 0.01) after HPS induction (Fig. 6); treatment with 0.5 mM NAC and BA at 25, 50 and 100 μg/ml both significantly (p < 0.01) reduced the expression of c-Jun and c-Fos. Here, JUN is linked to Hermansky-Pudlak syndrome.