HMGCR and Hypercholesterolemia: Isoprenoids are synthesized in the mevalonate (MEV) pathway alternatively/together with cholesterol whereby 3-hydroxy- 3-methylglutaryl coenzyme A reductase (HMGCR, E.C 1.1.1.34) is a step limiting enzyme, ubiquitously expressed in animal cells, and hampered by a group of hypercholesterolemia lowering drugs named statins.