We recently reported the synthesis of new anticancer anthra[2,3-b]furan-5,10-dione derivatives with different 4,11 side chains, showed that they potently inhibited the proliferation of various cancer cell lines, including some multidrug resistance sublines with deletion of the p53 gene, and further demonstrated that the cytotoxicity of these agents in cancer cells may be associated with the inhibition of tNOX [8]. The gene discussed is ENOX2; the disease is cancer.