DENV NS5 nuclear localisation is essential for productive infection, as indicated by the fact that specific mutations in NS5 preventing IMPα/β1 recognition result in an attenuated virus, and that specific inhibitors of NS5–IMPα/β1 interaction, such as the IMPα targeting agent ivermectin, are potent anti-DENV agents [7,12,13,14]; similar results have been recently reported for WNV [15] and ZIKV [16]. Here, IMPA1 is linked to infection.