PDGFB and glioblastoma: More recently, recombinant LV expressing a shRNA targeted to the Cyclin-dependent kinase Inhibitor 2A (Cdkn2a) and expressing the Platelet-Derived Growth Factor subunit B (PDGFB) were generated to induce proneural-type GBM growth in the dentate gyrus of immunocompetent mice, setting up an easy procedure for preclinical testing which does not require genetically engineered mice [103].