HRAS and glioblastoma: LV were used in immunocompetent mice to overexpress oncogenes under Cre-loxP control, inducing tumors in some brain regions of the adult mouse: the expression in specific cell types or regions (subventricular zone or hippocampus) of the activated forms of different oncoproteins such as H-Ras and AKT successfully induced GBM growth [99,100], pointing at LV overexpressing these factors under the control of Cre-loxP as a powerful tool for GBM generation.