Interestingly, in dissecting the role of HMGA2 in promoting GBM tumorigenicity, Kaur and colleagues not only silenced its transcript by shRNA-LV, as described above, by they also overexpressed HMGA2 in the HSR-GBM1 neurosphere cell line, further validating RNAi results [16]. Here, HMGA2 is linked to glioblastoma.