FOXO3 and colorectal carcinoma: Consistently, miR-592 levels were found to be elevated in CRC tissues and cells, leading to decreased FOXO3a mRNA and protein amounts [74], while overexpression of miR-551b in isolated primary ovarian cancer (OVCa) cells promoted proliferation, invasion, and chemoresistance of OVCa stem cells via the repression of FOXO3a and TRIM31 proteins [75].