The mechanism of action of protection against UV radiation by astaxanthin and fucoxanthin in glioma cells could be attributed to their ability to reactivate the MRN complex and its downstream factor 53BP1, leading to the reciprocal phosphorylation of ATR, thereby facilitating the process of DNA damage repair inhibition, as shown in Figure 2B,C. The gene discussed is TP53BP1; the disease is central nervous system cancer.