While AKT enzymes are poorly expressed or inactivated in ALS pathogenesis [32], the constitutive expression of AKT3 in motor neurons from G93A-SOD1 mice provides a neuroprotective effect with an increase of motor neuron survival when compared to cells expressing low levels of the enzyme in vitro and in vivo [33]. Here, SOD1 is linked to amyotrophic lateral sclerosis.