During the early stage of adipocyte differentiation, the potent inhibitory effects of active components on receptor tyrosine kinase, PI3K/AKT pathway, and AKT downstream factors, accompanied by the regulation of cell=cycle regulatory proteins and cell=cycle progression, suggest that phytochemicals might inhibit adipocyte differentiation and protect against obesity. The gene discussed is AKT1; the disease is obesity due to melanocortin 4 receptor deficiency.