BRCA1 and cancer: For example, a recent multigene hereditary cancer panel, including the genes BARD1, BRCA1, BRCA2, PALB2, and RAD51D, containing germline and somatic mutations found in this study, revealed that pathogenic germline variants in these genes are associated with high risk (odds ratio > 5.0) of TNBC, and greater than 20% lifetime risk for overall breast cancer among Caucasians [34].