The remodelling of the ovarian epithelium is further dependent on integrin-mediated upregulation of matrix metalloproteinases (MMPs), which in turn facilitate the ectodomain shedding of E-cadherin, resulting in decreased cell–cell adhesion and the detachment of ovarian cancer cells from the primary tumour into the peritoneal cavity (Figure 1). Here, CDH1 is linked to neoplasm.