ARF6 and neoplasm: As expected, EGFR and PDGFR were upregulated according to the malignancy grade of the tumor (Figure 1a,b), but other key players in macropinocytosis and methuosis were also upregulated according to the grade of the tumor, including actin dynamic-related gene products (SWAP70, several ARPC involved in the Arp2/3 complex), their upstream activator adenosine diphosphate ribosylation factors 6 (ARF6), and actin-rich membrane ruffles associated protein Rab34 (Figure 1d,f,h).