However, for the management of recurrent or metastatic ccRCC, targeted drug therapy is preferred; this includes the use of tyrosine kinase inhibitors such as sunitinib, sorafenib, axitinib and pazopanib; mammalian target of rapamycin (mTOR) inhibitors such as temsirolimus and everolimus; and monoclonal antibodies such as bevacizumab, which targets vascular endothelial growth factor (VEGF) [9,10]. The gene discussed is VEGFA; the disease is nonpapillary renal cell carcinoma.