These results showed that Caki-2 cells, which are known to express wild-type pVHL, expressed high levels of HIF-1α protein as expected; however, Caki-1 cells although classified as metastatic ccRCC and reported to be harboring wild-type VHL, did not express HIF-1α protein in our study. Here, VHL is linked to nonpapillary renal cell carcinoma.