Both Caki-1 and Caki-2 cells are primarily defined as human ccRCC cell lines; however, Caki-1 cell lines are metastatic ccRCC, harboring wild-type VHL, whereas, Caki-2 cell lines are considered as ccRCC expressing wild-type von Hippel-Lindau protein (pVHL) [15]. Here, VHL is linked to nonpapillary renal cell carcinoma.