Furthermore, we also found that RJ could reduce the Evans blue content, increase the expression level of LRP1 and inhibit the expression level of RAGE in the cholesterol-fed OVX rabbit brain, which may be beneficial to reduce cholesterol metabolism disorder, improve the permeability of BBB, and regulate the translocation of Aβ, thus reducing Aβ deposition in the brain. Here, AGER is linked to cholesterol metabolism disease.