Nuclear LDH is also increased by E7-induced ROS accumulation in cervical cancer cells, performs a non-canonical enzyme activity to produce α-hydroxybutyrate and triggers DOT1L mediated histone H3K79 hypermethylation, resulting in the activation of antioxidant responses and Wnt signalling pathway in cervical cancer cells [128]. Here, DOT1L is linked to cervical carcinoma.