IGF1 and breast cancer: Another study reported that formononetin also prevented the tumor growth of human breast cancer MCF-7 cells in nude mouse xenografts and caused cell cycle arrest at the G0/G1 phase by inactivating the IGF1/IGF1R-PI3K/Akt pathways, indicating the use of formononetin in the prevention of breast cancer carcinogenesis [121] (Figure 41).