Similarity, AS-IV could suppress the levels of inflammatory factors TGF-β1, TNF-α and IL-6 and also decrease the levels of EMT related factors integrin β1, MMP-2 and MMP-9 to inhibit migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway [137]. The gene discussed is NFKB1; the disease is lung cancer.