TRPM7 and Myocardial fibrosis: In a study of inhibiting hypoxia-induced myocardial fibrosis by AS-IV, it was observed that AS-IV could inhibit transient receptor potential cation channel, subfamily M, member 7 (TRPM7), decrease the intracellular calcium, decrease the α-smooth muscle actin (α-SMA, a marker of fibroblast differentiation), inhibit fibroblasts differentiation into fibroblasts and inhibit the expression of ECM and collagen I (a marker of cardiac fibroblasts) in vivo and in vitro [74] (Figure 15).