It was found that AR extract could significantly increase the population of CD4+CD25+Foxp3+ Treg cells, promote Foxp3+ mRNA expression, enhance Th2-mediated response and inhibit Th1-mediated response, thereby inhibiting the inflammation in a rat model of asthma, suggesting that the antiasthmatic effects of AR are at least partially associated with CD4+CD25+Foxp3+ Tregs [12] (Figure 51). The gene discussed is CD4; the disease is asthma.