NFKB1 and Parkinson disease: It was found that calycosin could attenuate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD by suppressing the activation of the TLR/NF-κB and MAPK pathways, indicating the potential drug of calycosin against PD [201] (Figure 67).