Of note, 4βHWE treatment suppressed the expression of the c-Myc, Axin2, cyclin D1, and survivin Wnt target genes in the tumor tissues, as well as the induction of Ser33/Ser37/Thr41 phosphorylation of β-catenin, indicating that 4βHWE inhibits Wnt signaling in vivo to attenuate tumor proliferation. Here, CCND1 is linked to neoplasm.