Further western blot analysis results showed that the expressions of the Wnt target genes Axin2, c-Myc, survivin, and cyclin D1 were significantly downregulated in the tumor tissues treated with 4βHWE (Figure 6D), with a slight decrease of β-catenin and an increase of Ser33/Ser37/Thr41 phosphorylation of β-catenin. Here, CCND1 is linked to neoplasm.