One of these key regulatory elements is the nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, a transcription factor involved in the control of the expression of several genes accounting for cisplatin chemoresistance commented above, such as MRP2 [49], and is up-regulated in high-risk HB [50]. The gene discussed is NFE2L2; the disease is hemoglobin measurement.