Though FUT6 seems to have a preference for the sialylated substrate, here, the results point towards the expression of mainly non-sialylated Lewis antigens via action of fucosylytransferases FUT3 (Lewis A) and FUT4 or FUT6 (Lewis X) [48] in the CDX1high colorectal cancer cell lines analyzed here. This evidence concerns the gene FUT4 and colorectal cancer.