While sialyl Lewis types antigens are commonly associated with (colorectal) cancers [8], the CDX1high cell lines show a very low expression of α2,3-sialylation, thereby limiting the substrate for specific fucosyltransferases involved in the expression of sialyl Lewis epitopes (FUT3,5,6,7). The combined expression of α2,3-sialylation and antenna fucosylation, as reflected in the trait CLFa, may be considered a proxy for sialyl Lewis epitope expression. The gene discussed is FUT3; the disease is cancer.