However, Bittel and colleagues [19] reported unequal parental expression bias compared with controls for the SHGC-32610 transcript located proximal to the D15S1035, a standard marker in the 15q11.2 BP1-BP2 region at that time and significantly increased in expression in lymphoblastoid cell lines established from individuals with Prader-Willi syndrome having either maternal disomy 15 or the paternal 15q11-q13 deletion. This evidence concerns the gene IGFBP2 and Prader-Willi syndrome.