UBE3A and precocious puberty, central, 2: Lastly, several genes in this broader region of chromosome 15 are methylated and known to cause genetic conditions with POEs, including Schaff-Yang syndrome (OMIM # 615547) with paternal loss of the imprinted MAGEL2 gene; Angelman syndrome (OMIM # 105830) with maternal loss of the imprinted UBE3A gene; Prader-Willi syndrome (OMIM # 176270) due to paternal loss of imprinted genes and transcripts in the 15q11-q13 region such as SNRPN; and central precocious puberty 2 (OMIM # 615346) with paternal loss of the imprinted MKRN3 gene.