They found that: (i) SSWP elicits robust IgE responses and sensitization, and mice show anaphylaxis when challenged; (ii) they showed for the first time that in this mouse model, anaphylaxis is linked to IgE-mediated mucosal mast cell degranulation [45,46]; and (iii) interestingly, some of the wheat allergic mice (but not all) developed atopic dermatitis lesions on the face, showing extensive mast cell degranulation and elevated levels of pro-inflammatory and allergic chemokines and cytokines (Table 2 and Table 4). The gene discussed is IGHE; the disease is anaphylaxis.