The IgE-mediated wheat allergies include three groups of disorders: (i) Occupational allergies, such as allergic rhinitis (AR), allergic conjunctivitis (AC), bakers asthma (BA), and contact urticaria (CU); (ii) wheat food allergy (WFA), such as atopic dermatitis (AD), gastrointestinal allergic disease, and systemic anaphylaxis [12,13,14,15]; and (iii) wheat-dependent exercise-induced anaphylaxis (WDEIA) [16,17,18]. Here, IGHE is linked to wheat allergic reaction.