Meanwhile, preclinical studies consistently showed that palm T3 (containing a mixture of TF and T3 isomers), annatto T3 (containing a mixture of T3 isomers), and individual T3 isomers exhibited potential skeletal-promoting effects in healthy animals [11,12] as well as in osteoporotic animals induced by various stressors, such as ovariectomy [13,14,15,16,17], orchidectomy [18,19,20,21], nicotine [22,23,24], alcohol [25], free radicals [26], glucocorticoid [27,28], buserelin [29,30], and metabolic syndrome (MetS) [31,32,33]. The gene discussed is TF; the disease is metabolic syndrome.