HGF and neoplasm: In the case of some patients with this type of tumor, there is a chromosomal aberration involving chromosomal translocation which leads to fusion with the MET gene and BAIAP2L1 or C8orf34. This results in protein coding with motifs that facilitate protein dimerization, fusion and ultimately promote c-Met receptor kinase activity, even in the absence of the HGF ligand [42].