Our group has already shown that in an in vitro model of clear cell renal cell carcinoma cells and in the normal human renal cell line HEK293, increased level and phosphorylation of c-Met correlates with the acquisition of mesenchymal cell characteristics, i.e. an increase in the migration activity, the suppression of E-cadherin and upregulated β-catenin and vimentin [44]. Here, MET is linked to clear cell renal carcinoma.